van Dam Lab - UCLA
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Titania-catalyzed radiofluorination of tosylated precursors in highly aqueous medium.

Sergeev, Maxim E Morgia, Federica Lazari, Mark Wang, Christopher Jr van Dam, R Michael

Published in Journal of the American Chemical Society

Nucleophilic radiofluorination is an efficient synthetic route to many positron-emission tomography (PET) probes, but removal of water to activate the cyclotron-produced [(18)F]fluoride has to be performed prior to reaction, which significantly increases overall radiolabeling time and causes radioactivity loss. In this report, we demonstrate the po...

Fully Automated Production of Diverse 18F-Labeled PET Tracers on the ELIXYS Multireactor Radiosynthesizer Without Hardwa...

Lazari, M. Jeffrey Collins Shen, B. Farhoud, M. Yeh, D. Maraglia, B. Chin, F. T. Nathanson, D. A. Moore, M. R. Michael van Dam ...

Published in Journal of Nuclear Medicine Technology

Compact microfluidic device for rapid concentration of PET tracers.

Tseng, Wei-Yu van Dam, R Michael

Published in Lab on a chip

HPLC purification and reformulation of positron emission tomography (PET) tracers can lead to significant dilution of the final product, making it difficult to produce a sufficiently high radioactivity concentration for some applications (e.g. small animal imaging, in vitro assays, and labelling of proteins with prosthetic groups). This is especial...

Efficient radiosynthesis of 3'-deoxy-3'-18F-fluorothymidine using electrowetting-on-dielectric digital microfluidic chip...

Javed, Muhammad Rashed Chen, Supin Kim, Hee-Kwon Wei, Liu Czernin, Johannes Kim, Chang-Jin C J van Dam, R Michael Keng, Pei Yuin

Published in Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Access to diverse PET tracers for preclinical and clinical research remains a major obstacle to research in cancer and other disease research. The prohibitive cost and limited availability of tracers could be alleviated by microfluidic radiosynthesis technologies combined with a high-yield microscale radiosynthetic method. In this report, we demons...

The separation and detection of PET tracers via capillary electrophoresis for chemical identity and purity analysis

Cheung, Shilin Ly, Jimmy Lazari, Mark Sadeghi, Saman Keng, Pei Yuin van Dam, R. Michael

Published in Journal of Pharmaceutical and Biomedical Analysis

CE coupled with UV detection was assessed as a possible platform for the chemical identity and purity analysis of positron emission tomography (PET) tracers using [18F]FAC and [18F]FLT as examples. Representative samples containing mixtures of the tracers plus well-known impurities, as well as real radioactive samples (formulated for injection), we...

Automated Reagent-Dispensing System for Microfluidic Cell Biology Assays PDF available through Get Fulltext Research

Jimmy Ly Masterman-Smith, M. Ramakrishnan, R. Sun, J. Kokubun, B. R. Michael van Dam

Published in Journal of Laboratory Automation

Simplified programming and control of automated radiosynthesizers through unit operations PDF available through Get Fulltext Research

Claggett, Shane B Quinn, Kevin M Lazari, Mark Moore, Melissa D van Dam, R Michael

Published in EJNMMI Research

BackgroundMany automated radiosynthesizers for producing positron emission tomography (PET) probes provide a means for the operator to create custom synthesis programs. The programming interfaces are typically designed with the engineer rather than the radiochemist in mind, requiring lengthy programs to be created from sequences of low-level, non-i...

ELIXYS - a fully automated, three-reactor high-pressure radiosynthesizer for development and routine production of diver... PDF available through Get Fulltext Research

Lazari, Mark Quinn, Kevin M Claggett, Shane B Collins, Jeffrey Shah, Gaurav J Herman, Henry E Maraglia, Brandon Phelps, Michael E Moore, Melissa D van Dam, R Michael ...

Published in EJNMMI Research

BackgroundAutomated radiosynthesizers are vital for routine production of positron-emission tomography tracers to minimize radiation exposure to operators and to ensure reproducible synthesis yields. The recent trend in the synthesizer industry towards the use of disposable kits aims to simplify setup and operation for the user, but often introduce...

Accurate dispensing of volatile reagents on demand for chemical reactions in EWOD chips.

Ding, Huijiang Sadeghi, Saman Shah, Gaurav J Chen, Supin Keng, Pei Yuin Kim, Chang-Jin C J van Dam, R Michael

Published in Lab on a chip

Digital microfluidic chips provide a new platform for manipulating chemicals for multi-step chemical synthesis or assays at the microscale. The organic solvents and reagents needed for these applications are often volatile, sensitive to contamination, and wetting, i.e. have contact angles of

On Chip Droplet Characterization: A Practical, High-Sensitivity Measurement of Droplet Impedance in Digital Microfluidic...

Sadeghi, Saman Ding, Huijiang Shah, Gaurav J. Chen, Supin Keng, Pei Yuin Kim, Chang-Jin “cj” R. Michael van Dam

Published in Analytical Chemistry

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