van Dam Lab - UCLA
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1 News 42 Publications 12 Members

Titania-catalyzed radiofluorination of tosylated precursors in highly aqueous medium.

Sergeev, Maxim E Morgia, Federica Lazari, Mark Wang, Christopher Jr van Dam, R Michael

Published in Journal of the American Chemical Society

Nucleophilic radiofluorination is an efficient synthetic route to many positron-emission tomography (PET) probes, but removal of water to activate the cyclotron-produced [(18)F]fluoride has to be performed prior to reaction, which significantly increases overall radiolabeling time and causes radioactivity loss. In this report, we demonstrate the po...

Fully Automated Production of Diverse 18F-Labeled PET Tracers on the ELIXYS Multireactor Radiosynthesizer Without Hardwa...

Lazari, M. Jeffrey Collins Shen, B. Farhoud, M. Yeh, D. Maraglia, B. Chin, F. T. Nathanson, D. A. Moore, M. R. Michael van Dam ...

Published in Journal of Nuclear Medicine Technology

The separation and detection of PET tracers via capillary electrophoresis for chemical identity and purity analysis

Cheung, Shilin Ly, Jimmy Lazari, Mark Sadeghi, Saman Keng, Pei Yuin van Dam, R. Michael

Published in Journal of Pharmaceutical and Biomedical Analysis

CE coupled with UV detection was assessed as a possible platform for the chemical identity and purity analysis of positron emission tomography (PET) tracers using [18F]FAC and [18F]FLT as examples. Representative samples containing mixtures of the tracers plus well-known impurities, as well as real radioactive samples (formulated for injection), we...

Efficient Radiosynthesis of 3 -Deoxy-3 -18F-Fluorothymidine Using Electrowetting-on-Dielectric Digital Microfluidic Chip...

Javed, M. R. Chen, S. Kim, H.-K. Wei, L. Czernin, J. Kim, C.-J. C. Michael Van Dam, R. Keng, P. Y.

Published in Journal of Nuclear Medicine

Automated Reagent-Dispensing System for Microfluidic Cell Biology Assays

Jimmy Ly Masterman-Smith, M. Ramakrishnan, R. Sun, J. Kokubun, B. R. Michael van Dam

Published in Journal of Laboratory Automation

Simplified programming and control of automated radiosynthesizers through unit operations

Claggett, Shane B Quinn, Kevin M Lazari, Mark Moore, Melissa D van Dam, R Michael

Published in EJNMMI Research

BackgroundMany automated radiosynthesizers for producing positron emission tomography (PET) probes provide a means for the operator to create custom synthesis programs. The programming interfaces are typically designed with the engineer rather than the radiochemist in mind, requiring lengthy programs to be created from sequences of low-level, non-i...

ELIXYS - a fully automated, three-reactor high-pressure radiosynthesizer for development and routine production of diver...

Lazari, Mark Quinn, Kevin M Claggett, Shane B Collins, Jeffrey Shah, Gaurav J Herman, Henry E Maraglia, Brandon Phelps, Michael E Moore, Melissa D van Dam, R Michael ...

Published in EJNMMI Research

BackgroundAutomated radiosynthesizers are vital for routine production of positron-emission tomography tracers to minimize radiation exposure to operators and to ensure reproducible synthesis yields. The recent trend in the synthesizer industry towards the use of disposable kits aims to simplify setup and operation for the user, but often introduce...

On Chip Droplet Characterization: A Practical, High-Sensitivity Measurement of Droplet Impedance in Digital Microfluidic...

Sadeghi, Saman Ding, Huijiang Shah, Gaurav J. Chen, Supin Keng, Pei Yuin Kim, Chang-Jin “cj” R. Michael van Dam

Published in Analytical Chemistry

Emerging Technologies for Decentralized Production of PET Tracers

keng, pei yuin esterby, melissa van dam, r. michael

Micro-chemical synthesis of molecular probes on an electronic microfluidic device

Keng, P. Y. Chen, S. Ding, H. Sadeghi, S. Shah, G. J. Dooraghi, A. Phelps, M. E. Satyamurthy, N. Chatziioannou, A. F. Kim, C.-J. C. ...

Published in Proceedings of the National Academy of Sciences

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